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The first two weeks of treatment, but it can take four to six weeks to see the full effect. Celexa appears to relieve depression by increasing serotonin without affecting many of the other chemicals in the brain. It makes your neurons soak for a longer period of time in the serotonin you already produce. Whether or not you are suffering from depression and if Celexa is the first choice for the treatment of depression ranges from 20 to 60 mg a day. You have any further queries regarding the medicine than contact your doctor.